Intrasubject variation of creatinine and specific gravity measurements in consecutive urine specimens of heroin users.

نویسندگان

  • B A Goldberger
  • B Loewenthal
  • W D Darwin
  • E J Cone
چکیده

116 CLINICAL CHEMISTRY, Vol. 41, No. 1, 1995 drugs in full-scan and selected.ion monitoring modes. Clin Chem 1994;40:216-20. 2. Doolittle MH, Lincoln K, Graves SW. Unexplained increase in serum digoxin: case report. Clin Chem 1994;40:487-92. 3. Critchfield GC, Wilkins DG, Loughmiller DL, Davis BW, Rollins DE. Antibody-mediated interference of a homogeneous immunoassay. J Anal Toxicol 1993;17:69-72. 4. Schwarzhoff R, Cody JT. The effects of adulterating agents on FPLA analysis of urine for drugs of abuse. J Anal Toxicol 1993;17: 14-7. 5. Poklis A, Hall KV, Still J, Binder SR. Ranitidine interference with the monoclonal EMIT d.a.u. amphetamine/methamphetamine immunoassay. J Anal Toxicol 1991;15:101-3. 6. Larsen J, Fogerson R. Nonsteroidal anti-inflammatory drug interference in TDx assays for abused drugs [Tech Brief]. Clin Chem 1988;34:987-8. 7. Rollins DE, Jennison TA, Jones G. Investigation of interference by nonsteroidal anti-inflammatory drugs in urine tests for abused drugs. Clin Chem 1990;36:602-6. 8. Greenblatt DJ, Maths R, Scavone JM, Blyden GT, Harmatz JS, Shader RI. Oxaprozin pharmacokinetics in the elderly. Br J Clin Pharmacol 1985;19:373-8. 9. Hale VG, Bashaw ED. Pharmacokinetics of oxaprozin. Clin Pharmacol 1993;12:255-6.

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Normalization of urinary drug concentrations with specific gravity and creatinine.

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BACKGROUND Specific gravity (SG) may perform as well as creatinine (CR) correction for adjusting urinary hormone concentrations, as well as offer some advantages. We compared the two methods and applied them to US and Bangladeshi specimens to evaluate their use in different populations. METHODS Pearson correlations between serum concentrations and SG, CR, and uncorrected urinary concentration...

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عنوان ژورنال:
  • Clinical chemistry

دوره 41 1  شماره 

صفحات  -

تاریخ انتشار 1995